New mRNA modification?
نویسندگان
چکیده
منابع مشابه
Implications of widespread covalent modification of mRNA.
W hole transcriptome analysis reveals that one third of human and mouse genes express mRNAs containing methylated adenosines. Fat mass and obesity-associated (FTO) gene, a risk gene for obesity and metabolic abnormalities , demethylates the modified residues, suggesting a link between RNA methylation and disease. Vertebrate ribosomal RNA (rRNA), transfer RNA (tRNA), messenger RNAs (mRNAs) as we...
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Among more than 140 naturally occurring RNA modifications have been identified, N6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification in eukaryotic organisms. A group of demethylases, methyltransferase and m6A-specific binding proteins in mammals, plants as well as yeast are in support of the regulatory functions of this RNA modification. Recent years, with the fast de...
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Ferrocenyl carbodiimide (1) could be used for the direct labeling of synthetic RNA and expressed mRNA in vitro with the electrochemically active ferrocene moieties. These RNAs modified by 1 could be detected electrochemically coupled with a DNA probe-immobilized electrode. After hybridization of 1.1 Kb mRNA modified by 1 with the DNA probe-immobilized electrode, the peak charge observed by an O...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2007
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1792iti5